美国匹兹堡大学医学中心UPMC移植外科吴国生教授放弃国外优越的工作环境及物质生活，依然决定回国发展，目前任西京消化病医院消化二科主任。他的这一决定必将带动我院移植外科的飞跃。吴国生教授擅长各类复杂肠瘘，短肠综合征的处理；及活体、尸体供体的小肠移植。以下附吴国生教授的简历。
职务和工作单位:
2010.12 – 现在 第四军医大学消化病医院消化二科主任、教授
医师执照:
美国医师执照
美国器官移植外科专科执照
中国医师执照（正在申请中）
工作简历:
2008.08 – 2010.11. 美国匹兹堡大学医疗中心器官移植外科主治医师、助理教授，移植专科医师
2006.07 – 2008.07. 美国迈阿密大学杰克逊纪念医院器官移植外科专科医师
2002.10 – 2006.07. 美国马里兰大学外科博士后、住院医师
2001.08 – 2002.09. 美国Vanderbilt大学医疗中心外科器官移植博士后
2001.07. 第四军医大学西京医院胃肠外科教授、主任医师
2001.06. 瑞典卡罗琳斯卡大学器官移植免疫学博士学位
1995.07 – 2001.06 瑞典卡罗琳斯卡大学 Huddinge 医院器官移植外科进修医师并攻读器官移植博士学位
1993.07 – 1995.06 第四军医大学西京医院胃肠外科主治医师
1988.07 – 1991.07 第四军医大学攻读外科硕士学位
1980.09 – 1985.08 兰州医学院医疗系
获奖情况：
2004.05 美国器官移植学会优秀青年研究者奖
2002.06 国际器官移植学会杰出青年研究者奖
2001.04 组织并成功完成中国首例活体小肠移植手术临床贡献 奖
2000.04 瑞典卡罗琳斯卡大学杰出青年研究人才奖
发表论文：
1. Wu GS, Korsgren O, Van Rooijen N, Wennberg L, Tibell A. The effect of macrophage depletion on delayed xenograft rejection: a study in the guinea pig-to-C6-deficient rat heart transplantation model. Xenotransplantation 1999; 6: 262.
2. Rafael E, Wernerson A, Wu GS, Arner P, Tibell A. In vivo evaluation of the glucose permeability of an immunoisolation device for islet transplantation. A novel application of the microdialysis technique. Cell Transplantation 1999; 8: 317.
3. Qian M, Wu GS, Adem A, Johnson AE, Sodersten P. CCK-8 inhibits ingestive behavior by acting on the liver. Neuroreport 1999; 10: 359.
4. Wu GS, Korsgren O, Wennberg L, Tibell A. Deoxyspergualin delays xenograft rejection in the guinea pig-to-C6-deficient rat heart transplantation model. Transplant Int 1999; 12: 415.
5. Wu GS, Korsgren O, Zheng ZG, Song ZS, Van Rooijen N, Tibell A. Porcine islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation 2000; 7: 214.
6. Rafael E, Gazelius B, Wu GS, Tibell A. Longitudinal studies on the microcirculation around the TheracyteTM immunoisolation device using laser Doppler technique. Cell Transplantation 2000; 9: 107.
7. Wu GS, Korsgren O, Tibell A. Suppression of T cells results in long-term survival of mouse heart xenograft in C6-deficient rats. Xenotransplantation 2001; 8(4):303.
8. Wu GS, Korsgren O, Wennberg L, Tibell A. Effect of plasma exchange in combination with deoxyspergualin on survival of guinea pig hearts in macrophage-depleted C6-deficient rats. Xenotransplantation 2003; 10(3): 214.
9. Schröder C, Wu GS, Price E, Johnson JE, Pierson III RN, Azimzadeh AM. Hyperacute rejection of mouse lung by human blood: characterization of the model and the role of complement. Transplantation 2003 Sep 15;76(5):755-60.
10. Schröder C, Pfeiffer S, Wu GS, Pierson RN 3rd, Azimzadeh AM. Effect of C1 Esterase Inhibition on Survival of h-DAF Pig Lungs perfused with human blood. J Heart Lung Transpl 2003;22:1365-75.
11. Schroder C, Azimzadeh A, Wu GS, Price J, Atkinson J, Pierson R. Anti-CD20 treatment depletes B-cells in blood and lymphatic tissue of cynomolgus monkeys. Transpl Immunol. 2003 12:19-28.
13. Wu GS, Pfeiffer S, Schroder C, Zhang TS, Nguyen BN, Lea W, Kelishadi S, Atkinson JB, Schuurman HJ, White DJG, Azimzadeh AM, Pierson III RN. Co-stimulation blockade targeting CD154 and CD28/B7 modulates the induced antibody response after a pig-to-baboon cardiac xenograft. Xenotransplantation 2005; 12: 197-208.
14. Azimzadeh AM, Pfeiffer S, Wu GS, Schroder C, Atkinson JB, Miller GG, Pierson III RN 3rd. Humoral immunity to vimentin is associated with cardiac allograft injury in nonhuman primates. Am J Transplant 2005; 5(10): 2349-59.
15. Azimzadeh AM, Pfeiffer S, Wu GS, Schroder C, Zorn GL 3rd, Kelishadi SS, Ozkaynak E, Kehry M, Atkinson JB, Miller GG, Pierson III RN 3rd.
Alloimmunity in primate heart recipients with CD154 blockade: evidence for alternative costimulation mechanisms. Transplantation 2006; 81(2): 255-64.
16. Schroder C, Pfeiffer S, Wu GS, Azimzadeh AM, Aber A, Pierson III RN 3rd, O’Sullivan MG. Simian parvivirus infection in cynomolgus monkey heart transplant recipients causes death related to severe anemia. Transplantation 2006; 81(8): 1165-70.
17. Schroder C, Pierson RN 3rd, Nguyen BN, Peterson LB, Wu GS, Zhang T, et al. CCR5 blockade modulates inflammation and alloimmunity in primates. J Immunol 2007; 179(4): 2289-99.
18. Nguyen BN, Azimzadeh AM, Zhang T, Wu GS, Shuurman HJ, Sachs DH, Ayares D, Allan JS, Pierson RN 3rd. Life-supporting function of genetically modified swine lungs in baboons. J Thorac Cardiovasc Surg 2007; 133(5): 1354-63.
19. Wu GS, Pfeiffer S, Schroder C, Zhang T, Nguyen BN, Kelishadi S, Atkinson JB, Schuurman HJ, White DJ, Azimzadeh AM, Pierson RN 3rd. Coagulation cascade activation triggers early failure of pig hearts expressing human complement regulatory genes. Xenotransplantation 2007; 14(1): 34-47.
20. Wu GS, Kato T, Selvaggi G, Island E, Levi DM, Nishida S, Moon J, Thompson TF, Ruiz P, Gaynor JJ, Tzakis AG. Graft versus host disease after intestinal and multivisceral transplantation. Transplantation (in press).
21.
Cruz RJ Jr,
Costa G,
Bond G,
Soltys K,
Stein WC,
Wu G,
Martin L,
Koritsky D,
McMichael J,
Sindhi R,
Mazariegos G,
Abu-Elmagd KM. Modified "liver-sparing" multivisceral transplant with preserved native spleen, pancreas, and duodenum: technique and long-term outcome. J Gastrointest Surg 2010; 14(11): 1709-21.
22. Guosheng Wu, John Lunz, Guiherme Costa, Geoffrey Bond, Ruy Cruz, Kyle Soltys, George Mazariegos, Rakesh Sindhi, Adrianna Zeevi, Kareem Abu-Elmagd. Donor specific antibodies and outcome of small bowel allograft allograft rejection (manuscript).
论文摘要：
1. Wu GS, Korsgren O, Tibell A. Cyclosporine induces long-term xenograft survival in the mouse-to-C6-deficient rat heart transplantation model. Transplantation Proc 2000; 32(5): 1015.
2. Wu GS, Korsgren O, Zheng ZG, Song ZS, Van Rooijen N, Tibell A. Role of macrophages and natural killer cells in the rejection of pig islet xenografts in mice. Transplantation Proc 2000; 32(5): 1069.
3. Wu GS, Wang WZ, Song WL, Lin R, Duraj F. Living-related small bowel transplantation: the first case in China. Transplantation Proc 2000; 32: 1218.
4. Wu GS, Petersson S, Spiik AK, Korsgren O, Tibell A. Antisense NF-kappaB p65 prolongs experimental allo- and xenograft survival. Transplant Proc 2001; 33 (1-2): 360.
5. Azimzadeh A, Wu GS, Ozkaynak E, Pierce J, Pfeiffer S, Schroeder C, Zorn G, Newman R, Atkinson J, Pierson RNIII. ICOS expression in monkey heart allografts under CD154 costimulation blockade. Transplantation Suppl. 74; 4: 172.
6. Pierson III RN, Schroeder C, Wu GS, Kawka DW, Peterson L, Springer MS, Siciliano SJ, Lyons K, Mills, S, Illiff S, Miller GG, Azimzadeh AM, Singer II, DeMartino, JA. Synergism between CCR5 blockade and CSA in primate cardiac allotransplantation. Transplantation Suppl. 74; 4: 299.
7. Schröder C, Wu GS, Price E, Ding L, Lee GK, Pierson III RN, Azimzadeh AM. Inhibition of complement (sCR1 & C1-Inh) in a novel ex-vivo mouse lung xenogenic model. Transplantation Suppl. 74; 4: 629.
8. Azimzadeh A, Wu GS, Ozkaynak E, Pierce J, Pfeiffer S, Schroeder C, Zorn G, Newman R, Atkinson J, Pierson RNIII. ICOS expression in monkey heart allografts under CD154 costimulation blockade (poster presentation at ATC, Washington D.C., 2003)
9. Azimzadeh A, Schroeder C, Wu GS, Miller J, Pierson RNIII. IFNg and IL-10 modulation in monkey heart allografts under CD154 costimulation blockade (oral presentation at ATC, Washington D.C., 2003).
10. Schröder C, Wu GS, Pierson RN 3rd, Azimzadeh AM. Hyperacute rejection of mouse lung by human blood: characterization of the model and the role of complement (poster presentation at ATC, Washington D.C., 2003).
11. Schröder C, Azimzadeh AM, Wu GS, Pierson RN 3rd. CD154 blockade spares secondary immunity to influenza in primates (oral presentation at ATC, Washington D.C., 2003).
12. Schröder C, Allan JS, Nguyen BN, Wu GS, Zhang TS, Azimzadeh AM, Madsen JC, Schuurman HJ, Sachs DH, Pierson RN 3rd. Hyperacute rejection is attenuated in GalT knockout swine lungs perfused ex vivo with human blood. Transplant Proc 2005; 37(1): 512-3.
13. Wu GS, Schroder C, Pfeiffer S, Zhang TS, Nguyen BN, Atkinson JB, Schuurman HJ, White DJG, Azimzadeh AM, Pierson III RN. Mechanisms of hyperacute rejection of hDAF- or MCP-transgenic pig hearts in baboons. Am J Transplant 2005 (5, suppl 11): 371.
14. Zhang TS, Zhou H, Kechang Liu, Egon Zwets, Wu GS, O’hara R, Pierson III RN, Azimzadeh AM. Effect of anti-CD28 scFv antibody plus MR1 or CsA on mouse heart allograft survival. Am J Transplant 2005 (5, suppl 11): 514.
21. Wu GS, Lunz J, Costa G, Bond G, Cruz R, Soltys K, Mazariegos G, Sindhi R, Zeevi A, Abu-elmagd. Donor specific anti-HLA antibodies and outcome of small bowel allograft allograft rejection (oral presentation in Am Transplant Congress 2010).
22. Wu GS, Lunz J, Costa G, Bond G, Cruz R, Soltys K, Mazariegos G, Sindhi R, Zeevi A, Abu-elmagd. Donor specific anti-HLA antibodies after multivisceral transplantation with special reference to the liver (oral presentation in International Transplant Society 2010)
会员：
国际器官移植学会会员
美国器官移植学会会员
